Neuroinflammation in the Dorsal Root Ganglia and Dorsal Horn Contributes to Persistence of Nociceptor Sensitization in SIV-infected ART-treated Macaques

Despite the development of antiretroviral therapy (ART), human immunodeficiency virus (HIV)-associated distal sensory polyneuropathy (HIV-DSP) has remained prevalent. Using simian immunodeficiency virus (SIV)-infected rhesus macaques, we examined molecular mechanisms of peripheral and central sensitization to infer chronic pain from HIV infection. Previous studies identified atrophy in nociceptive neurons during SIV infection, which was associated with monocyte infiltration into the dorsal root ganglia (DRG).

https://ajp.amjpathol.org/article/S0002-9440(23)00325-5/fulltext?rss=yes

Source: American Journal of Pathology - September 19, 2023 Category: Pathology Authors: Rebecca Warfield, Jake A. Robinson, Rachel M. Podgorski, Andrew D. Miller, Tricia H. Burdo Tags: Regular Article Source Type: research