Fracture Rate After Conventional External Beam Radiation Therapy to the Spine in Multiple Myeloma Patients

Multiple myeloma (MM) is an incurable hematologic malignancy that accounts for approximately 1% of all neoplastic diseases worldwide [1]. Distinctive for MM is infiltration and proliferation of monoclonal plasma cells in the bone marrow. This can lead to disturbances in the ratio between bone resorption and bone formation, causing osteolytic lesions and secondary osteoporosis with a reduced bone mass [2]. Osteolytic lesions are present in about 80% of newly diagnosed MM patients and negatively impact the already increased mortality and morbidity [3].

Source: The Spine Journal - September 19, 2023 Category: Orthopaedics Authors: Jens P. te Velde, Hester Zijlstra, Amanda Lans, Chirayu G. Patel, Noopur Raje, Diyar Delawi, Diederik H.R. Kempen, Jorrit-Jan Verlaan, Barend J. van Royen, Joseph H. Schwab Tags: Clinical Study Source Type: research