CoCl2-mimicked hypoxia induces the assembly of stress granules in trophoblast cells via eIF2 α phosphorylation-dependent and -independent pathways

CONCLUSION: Mechanistically, both heme-regulated inhibitors (HRI) mediated eukaryotic translation initiation factor (eIF)2α phosphorylation pathway and 4E binding protein 1 (4EBP1) pathway are involved in SG formation under the stress of CoCl2-mimicked hypoxia. Hypoxia-induced SGs in trophoblast cells might contribute to the etiology of PE.PMID:37711098 | DOI:10.2174/1566524023666230913111300
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Source Type: research