Evaluation of collagen turnover biomarkers as an objective measure for efficacy of treatment with rurioctocog alfa pegol in Hemophilia A patients: a secondary analysis of a randomized controlled trial

CONCLUSION: Joint improvement measured by collagen remodelling biomarkers specific to the basement membrane, interstitial matrix, and cartilage was seen with pharmacokinetics-guided prophylaxis. These collagen remodeling biomarkers warrant further exploration as biomarkers to guide treatment toward improvement in HA.PMID:37717853 | DOI:10.1016/j.jtha.2023.08.035

Source: Thrombosis and Haemostasis - September 17, 2023 Category: Hematology Authors: Tina Manon-Jensen Srilatha Tangada Cecilie Bager Pratima Chowdary Robert Klamroth Annette von Drygalski Jerzy Windyga Miguel Escobar Peder Frederiksen Werner Engl Bruce Ewenstein Morten Karsdal Source Type: research