Antiviral Isoquinolines from the Cigar Tobacco Derived Endophytic Fungi Aspergillus fumigatus

With the aim of screening more antiviral activity metabolites, in this study, two new (1 and2), together with five known (3 –7), isoquinolines were isolated from the cigar tobacco-derived endophytic fungi Aspergillus fumigatus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Interestingly, the anti-TMV activities test revealed that compounds1 and2 showed potential anti-TMV activities with inhibition rates of 31.2 and 28.5%, respectively.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research