Curcumin Compensates GLP ‐1 Deficiency via the Microbiota‐Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice

ConclusionsThe findings suggest that Cur may act as a natural TGR5 agonist and FXR antagonist to improve obesity by enhancing GLP-1 release from L-cell expansion via the gut microbiota-BAs-TGR5/FXR axis, and it may serve as a promising therapeutic agent to compensate obesity-related metabolic disorders.

Source: Molecular Nutrition and Food Research - September 15, 2023 Category: Food Science Authors: Fengyuan Tian, Tianxi Chen, Wangda Xu, Yichang Fan, Xiaohong Feng, Qi Huang, Jie Chen Tags: Research Article Source Type: research