Corticostriatal beta oscillation changes associated with cognitive function in Parkinson ’s disease

The objective of our study is to evaluate whether changes in beta oscillations in the caudate and DLPFC contribute to cognitive impairment in Parkinson’s disease patients. To investigate this, we used local field potential recordings during deep brain stimulation surgery in 15 patients with Parkinson’s disease. Local field potentials were recorded from DLPFC and caudate at rest and during a working memory task. We examined changes in beta oscillatory power during the working memory task as well as t he relationship of beta oscillatory activity to preoperative cognitive status, as determined from neuropsychological testing results. We additionally conducted exploratory analyses on the relationship between cognitive impairment and task-based changes in spectral power in additional frequency bands .Spectral power of beta oscillations decreased in both DLPFC and caudate during working memory encoding and increased in these structures during feedback. Subjects with cognitive impairment had smaller decreases in caudate and DLPFC beta oscillatory power during encoding. In our exploratory analysis , we found that similar differences occurred in alpha frequencies in caudate and theta and alpha in DLPFC.Our findings suggest that oscillatory power changes in cognitive CSTC circuits may contribute to cognitive symptoms in patients with Parkinson’s disease. These findings may inform the future d evelopment of novel neuromodulatory treatments for cognitive impairment in Parkinson’s...
Source: Brain - Category: Neurology Source Type: research