Carboline Alkaloids from the Cigar Tobacco-Derived Fungi Aspergillus sp. and Their Anti-TMV Activity

Two newβ-carboline alkaloids, 1-acetyl-6-hydroxymethyl-7-methoxy-β-carboline (1) and 1-acetyl-6- hydroxymethyl-8-methoxy-β-carboline (2), together with four known ones (3 –6) were isolated from the cigar tobacco (a variety ofNicotiana tabacum L.)-derived endophytic fungiAspergillus sp. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The anti-TMV activities test revealed that compounds1 and2 showed potential anti-TMV activities with inhibition rates of 31.8 and 35.5%, respectively. These rates are close to that of positive control. Compounds3 –6 also showed anti-TMV activities with inhibition rates in the range of 21.5 –28.8%, respectively. The isolation of the aforementionedβ-carboline alkaloids may provide materials for the screening of anti-TMV activity inhibitors and contribute to the utilization of cigar tobacco-derived endophytic fungi.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research