Cervical Intraepithelial Neoplasia grade 2 biopsy: Do p16INK4a and Ki-67 biomarkers contribute to the decision to treat? A cross-sectional study

CONCLUSIONS: Negative p16INK4a and Ki67 immunohistochemical staining can assure absence of a higher-grade lesion in more than 85% of patients with CIN2 biopsies and can be used to prevent overtreatment of these patients. Positive IHC staining for p16INK4a and Ki-67 did not predict CIN3 in patients with CIN2 biopsies.PMID:37646766 | PMC:PMC10452003 | DOI:10.1590/1516-3180.2022.0527.R2.280423

Source: Sao Paulo Medical Journal - August 30, 2023 Category: General Medicine Authors: Amanda Leal Ferreira Nasle Domingues Dibe Bruna Rodrigues de Paiva Elyzabeth Avvad Portari Dione Corr êa de Araújo Dock Nilma Val éria Caldeira Ferreira Saint Clair Gomes Junior F ábio Bastos Russomano Cec ília Vianna de Andrade Source Type: research