Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway

Conclusions/interpretation These results demonstrate that FGF21 prevents lipid- or diabetes-induced cardiac apoptosis by activating the ERK1/2–p38 MAPK–AMPK pathway. FGF21 may be a therapeutic target for the treatment of diabetes-related cardiac damage.

http://link.springer.com/10.1007/s00125-015-3630-8

Source: Diabetologia - June 4, 2015 Category: Endocrinology Source Type: research