Seven new secondary metabolites isolated from roots of Lespedeza bicolor

Fitoterapia. 2023 Sep 6:105671. doi: 10.1016/j.fitote.2023.105671. Online ahead of print.ABSTRACTChemical investigation of a methanol extract obtained from the roots of Lespedeza bicolor identified one new pterocarpene (1), three new pterocarpans (2-4), and three new arylbenzofurans (5-7), and two known compounds (8 and 9). Their structures were determined by interpretations obtained from combined UV, NMR, and HRTOFMS spectroscopic data. Furthermore, the absolute configurations of compounds 2 and 3 were established by the combination of electronic circular dichroism (ECD) calculations and NMR calculations with DP4+ probability analysis. All isolated compounds (1-9) were evaluated for cytotoxicity against the human lung carcinoma cell line A549 and the human hepatoma cell line Huh-7. Compound 4 showed antiproliferative activity against A549 cell line with IC50 value of 24.9 μM. Furthermore, compound 9 exhibited cytotoxicity against Huh-7 cell line with IC50 value of 68.7 μM.PMID:37683875 | DOI:10.1016/j.fitote.2023.105671
Source: Fitoterapia - Category: Biochemistry Authors: Source Type: research