DNA Methyltransferase 3A: a Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs

Mini Rev Med Chem. 2023 Aug 25. doi: 10.2174/1389557523666230825100246. Online ahead of print.ABSTRACTDNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential of DNMT3A in certain diseases is a significant task. In this review, we summarized the small molecule inhibitors of DNMT3A discovered in recent years and their inhibitory activities, and classified them based on their inhibitory mechanisms.PMID:37642180 | DOI:10.2174/1389557523666230825100246
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research