Switching from intravenous vancomycin to oral antibiotics reduces adverse events in a retrospective cohort of outpatients with orthopedic infections

ConclusionsPatients transitioned to oral therapy within 4  weeks of discharge had significantly fewer adverse events and similar incidences of one-year treatment failure compared to patients maintained on parenteral vancomycin. Substituting oral antibiotics for parenteral vancomycin is a potential strategy to minimize vancomycin toxicity during the treat ment of orthopedic infections.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - September 9, 2023 Category: Drugs & Pharmacology Authors: Chanah K. Gallagher, Heather Cummins, Russell J. Benefield, Laura K. Certain Tags: RESEARCH ARTICLE Source Type: research