Guiding the Path to Healing: CuO2 ‐Laden Nanocomposite Membrane for Diabetic Wound Treatment

Electrospun fibers with then-CuO2 NPs loaded PVP/PCL as the sheath and PCL as the core. When exposed to the wound's moist environment, PVP disintegrates to release the embeddedn-CuO2, to trigger the H2O2 self-supplied chemodynamic therapy (CDT) for antibacterial, antiinflammation, and angiogenesis properties. Simultaneously, the dissolution of PVP also exposes nano-grooved patterns for cell-guiding function to accelerate skin regeneration. AbstractDiabetic chronic wounds pose significant clinical challenges due to their characteristic features of impaired extracellular matrix (ECM) function, diminished angiogenesis, chronic inflammation, and increased susceptibility to infection. To tackle these challenges and provide a comprehensive therapeutic approach for diabetic wounds,  the first coaxial electrospun nanocomposite membrane is developed that incorporates multifunctional copper peroxide nanoparticles (n-CuO2). The membrane's nanofiber possesses a unique “core/sheath” structure consisting ofn-CuO2+PVP (Polyvinylpyrrolidone)/PCL (Polycaprolactone) composite sheath and a PCL core. When exposed to the wound's moist environment, PVP within the sheath gradually disintegrates, releasing the embeddedn-CuO2. Under a weakly acidic microenvironment (typically diabetic and infected wounds),n-CuO2 decomposes to release H2O2 and Cu2+ ions and subsequently produce ·OH through chemodynamic reactions. This enables the anti-bacterial activity mediated by reactive oxygen species (ROS)...

Source: Small - September 9, 2023 Category: Nanotechnology Authors: Lin Qi, Yong Huang, Dan Sun, Zheng Liu, Yulin Jiang, Jiangshan Liu, Jing Wang, Limin Liu, Ganjun Feng, Yubao Li, Li Zhang Tags: Research Article Source Type: research