Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas

CONCLUSIONS: Our findings suggest that CaSR activator cinacalcet has antidiarrheal efficacy in distinct human cell, organoid and mouse models of secretory diarrhea. Considering its excellent clinical safety profile, cinacalcet can be repurposed as a treatment for secretory diarrheas including cholera.PMID:37678755 | DOI:10.1016/j.trsl.2023.09.001

Source: Cell Research - September 7, 2023 Category: Cytology Authors: Tifany Chu Pattareeya Yottasan Livia de Souza Goncalves Apurva A Oak Ruxian Lin Ming Tse Mark Donowitz Onur Cil Source Type: research