Sensing mitochondrial DNA stress in cardiotoxicity

Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012

Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research