Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas

: Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea treatment is primarily supportive, and oral rehydration solution is the mainstay of cholera treatment. There is an unmet need for safe, simple and effective diarrhea treatments. By promoting cAMP hydrolysis, extracellular calcium-sensing receptor (CaSR) is a regulator of intestinal fluid transport.

Source: Translational Research - September 5, 2023 Category: Research Authors: Tifany Chu, Pattareeya Yottasan, Livia de Souza Goncalves, Apurva A. Oak, Ruxian Lin, Ming Tse, Mark Donowitz, Onur Cil Source Type: research