Differential changes in the gut microbiota between extrinsic and intrinsic atopic dermatitis

J Autoimmun. 2023 Aug 24:103096. doi: 10.1016/j.jaut.2023.103096. Online ahead of print.ABSTRACTElevated serum level of total and (or) allergen-specific IgE is one of the key features of atopic dermatitis (AD). Previous studies have shown that the gut microbiome mediates interactions between external exposures and the immune system in AD; however, the relationship between the gut microbiota and IgE remains unclear. In the present study, analyses of environmental exposures for 250 AD patients and 138 healthy volunteers revealed an association between hygiene levels in the residential environment and the occurrence of AD and the IgE level. Metagenomic sequencing of the gut microbiota from 68 AD patients and 77 healthy controls showed that AD patients had a distinct gut microbiota composition; moreover, while L-histidine degradation was enriched in healthy controls, L-histidine biosynthesis was enriched in AD patients. Extrinsic and intrinsic AD showed different enrichment patterns of specific microbes and differential associations of functional pathways. Our study indicated that elevated levels of IgE in AD were related to specific microbes in the gut microbiota, which showed extensive interactions with environmental factors.PMID:37633814 | DOI:10.1016/j.jaut.2023.103096
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Source Type: research