Fabrication of a bifunctional fluorescent chiral composite based on magnetic Fe < sub > 3 < /sub > O < sub > 4 < /sub > /chiral carbon dots@hierarchical porous metal-organic framework

Talanta. 2023 Aug 28;266(Pt 2):125113. doi: 10.1016/j.talanta.2023.125113. Online ahead of print.ABSTRACTConsidering the selective pharmacological activity and ecotoxicity of chiral drugs, the development of chiral materials with the dual functions of enantiomeric recognition and adsorption is of great significance. Herein, a novel bifunctional chiral composite (Fe3O4/CCDs@HP-ZIF-8) which does not contain expensive and rare fluorescent chiral ligands or metal ions, was constructed for the first time by encapsulating chiral carbon dots (CCDs) and magnetic Fe3O4 nanoparticles into hierarchical porous metal-organic frameworks (HP-MOFs). Fe3O4/CCDs@HP-ZIF-8, which integrates fluorescent chiral property, magnetism, and hierarchical porosity, shows enormous potential in enantiomeric recognition and adsorption. Fluorescence detection results demonstrate that Fe3O4/CCDs@HP-ZIF-8 presents different fluorescence quenching for naproxen enantiomers. The limits of detection are determined to be 0.05 μM for S-naproxen (S-Nap) and 0.30 μM for R-naproxen (R-Nap), respectively. Furthermore, the isothermal, kinetic, and thermodynamic adsorption behaviors of Fe3O4/CCDs@HP-ZIF-8 to naproxen enantiomers were systematically studied. Due to its hierarchical porosity, the composite exhibits higher adsorption capacity to naproxen enantiomers compared to the non-hierarchical porous composite. Studies of enantiomeric recognition and adsorption mechanisms affirm that the synergistic effect of multiple...
Source: Talanta - Category: Chemistry Authors: Source Type: research