Maternal vitamin D –related metabolome and offspring risk of asthma outcomes

Vitamin D deficiency in childhood has been associated with various adverse health consequences as 25-hydroxyvitamin D (25(OH)D) possesses a range of immune regulatory properties with potential implications for proneness to respiratory infection, allergies, and asthma.1,2 Studies have further shown that 25(OH)D deficiency during pregnancy may affect fetal immune programming, consequently increasing the risk of asthma in early childhood.3,4 Therefore, we recently performed an intervention study in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort,5 which showed beneficial effects of high-dose versus standard-dose of vitamin D supplementation (2800 IU/day vs 400 IU/day) during pregnancy on episodes of troublesome lung symptoms (TROLS),6 persistent wheeze,7 and croup.

Source: Journal of Allergy and Clinical Immunology - August 7, 2023 Category: Allergy & Immunology Authors: Min Kim, Nicklas Brustad, Mina Ali, G özde Gürdeniz, Morten Arendt, Augusto A. Litonjua, Craig E. Wheelock, Rachel S. Kelly, Yulu Chen, Nicole Prince, Feng Guo, Xiaobo Zhou, Jakob Stokholm, Klaus Bønnelykke, Scott T. Weiss, Hans Bisgaard, Jessica Lasky Source Type: research