Dupilumab strengthens HSV-1 specific immune responses in atopic dermatitis

Impaired viral clearance in a subgroup of atopic dermatitis (AD) patients can lead to severe herpes simplex virus (HSV) infections named eczema herpeticum (EH). We recently identified a type 2 skewed viral immune response in EH patients. Clinical data suggest a reduced incidence of EH in AD patients treated with dupilumab, however, immunological investigations of this phenomenon are still lacking.

https://www.jacionline.org/article/S0091-6749(23)01106-5/abstract?rss=yes

Source: Journal of Allergy and Clinical Immunology - September 1, 2023 Category: Allergy & Immunology Authors: Stephan Traidl, Leonard Harries, Petra Kienlin, Gabriele Begemann, Lennart M. Roesner, Thomas Werfel Source Type: research