The pathophysiological impact of intra-abdominal hypertension in pigs

by Robert Wise, Reitze Rodseth, Ester P árraga-Ros, Rafael Latorre, Octavio López Albors, Laura Correa-Martín, Francisco M. Sánchez-Margallo, Irma Eugenia Candanosa-Aranda, Jan Poelaert, Gregorio Castellanos, Manu L. N. G. Malbrain BackgroundIntra-abdominal hypertension and abdominal compartment syndrome are common with clinically significant consequences. We investigated the pathophysiological effects of raised IAP as part of a more extensive exploratory animal study. The study design included both pneumoperitoneum and mechanical intestinal obstruction models. MethodsForty-nine female swine were divided into six groups: a control group (Cr; n = 5), three pneumoperitoneum groups with IAPs of 20mmHg (Pn20; n = 10), 30mmHg (Pn30; n = 10), 40mmHg (Pn40; n = 10), and two mechanical intestinal occlusion groups with IAPs of 20mmHg (MIO20; n = 9) and 30mmHg (MIO30; n = 5). ResultsThere were significant changes (p
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research