Chronic inflammation can transform the fate of normal and mutant haematopoietic stem cells

Hematopoietic stem cells (HSCs) are at the top of the blood hierarchy and are responsible for the production of all blood cells after birth [1]. They emerge during the first days of gestation (27 days post-conception in humans, 10.5 days post-conception in mice) on the ventral side of the aorta-gonad-mesonephros through a process called endothelial-to-hematopoietic transition, after which they migrate and expand in the foetal liver and bone marrow [2-4]. Some HSCs remain quiescent to maintain their ability to self-renew, some duplicate, some differentiate into a specific blood cell lineage, and some migrate outside their niche to circulate in the blood [5].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research