Activity of compounds derived from benzofuroxan in Trichomonasvaginalis

This study evaluated the in vitro antiparasitic activity of these compounds in trophozoites of T. vaginalis and determined the mean inhibitory concentration (IC50), minimum inhibitory concentration (MIC), mortality curve, and cytotoxicity. The compounds were named EH1, EH2, EH3, and EA2 and tested in various concentrations: 100 to 15 μM (EH1 and EH2); 100 to 5 μM (EH3); and 100 to 25 μM (EA2), respectively. The greatest efficacy was observed in the highest concentrations in 24 h, with inhibition of approximately 100% of trophozoites. Compounds EH2 and EH3 had the lowest MIC: EH2 (35 μM) and EH3 (45 μM), with IC50 of 11.33 μM and 6.83 μM, respectively. Compound EA2 was effective at the highest concentrations. The activity of the compounds in T. vaginalis started in the first hour of incubation with 90% inhibition; after 12 h, inhibition >95% was observed. Compound EH1 showed the lowest activity, with the highest activity between 12 and 24 h after incubation. These results demonstrate that benzofuroxan derivatives are promising compounds for the in vitro treatment of T. vaginalis.PMID:37625643 | DOI:10.1016/j.exppara.2023.108601

Source: Experimental Parasitology - August 25, 2023 Category: Parasitology Authors: Marjorie Giacometi Jo ão Cândido Pilar Mayer Alexia Brauner de Mello Yan Wahast Islab ão Adriane Leites Strothmann Renata Nobre Fonseca Ângela Sena-Lopes Luciano Dornelles Sibele Borsuk Silvia de Oliveira H übner Camila Belmonte Oliveira Source Type: research