Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension

CONCLUSIONS: Increase in MMP-2 activity proteolyzes type I collagen in the aortas of 2K1C rats and contributes to activate FAK and induces VSMC proliferation during the initial phase of hypertension.PMID:37607602 | DOI:10.1016/j.vph.2023.107211

Source: Vascular Pharmacology - August 22, 2023 Category: Drugs & Pharmacology Authors: Viviano Gomes de Oliveira Neves Marcela M Blascke de Mello Daniel Rodrigues Laena Pernomian Isadora Sousa de Oliveira Juliana M Parente Eliane Candiani Arantes Rita Tostes Michele M Castro Source Type: research