Diagnostic performance of prediction models for extraprostatic extension in prostate cancer: a systematic review and meta-analysis

ConclusionPreoperative risk stratification is essential for PCa patients; both MRI-inclusive nomograms and traditional clinical nomograms had moderate diagnostic performance for predicting EPE in PCa. This study provides baseline comparative values for EPE prediction for future studies which is useful for evaluating preoperative risk stratification in PCa patients.Critical relevance statementThis meta-analysis firstly evaluated the diagnostic performance of preoperative MRI-inclusive nomograms and clinical nomograms for predicting extraprostatic extension (EPE) in prostate cancer (PCa) (moderate AUCs: 0.72 –0.80). We provide baseline estimates for EPE prediction, these findings will be useful in assessing preoperative risk stratification of PCa patients.Key points• MRI-inclusive nomograms and traditional clinical nomograms had moderate AUCs (0.72–0.80) for predicting EPE.• MRI combined clinical nomogram may improve diagnostic accuracy of MRI alone for EPE prediction.• MSKCC nomogram had a higher specificity than Partin table for predicting EPE.• This meta-analysis provided baseline and comparative estimates of nomograms for EPE prediction for future studies.Graphical Abstract

Source: Insights into Imaging - August 22, 2023 Category: Radiology Source Type: research