Glyphosate is Harmful to Early Life Stages of the Viviparous Fish Jenynsia Multidentata: Biochemical and Locomotor Effects

In this study, we assessed the effects of environmentally relevant concentrations of glyphosate (30-100 µg/L) on the early life stages of the viviparous fish Jenynsia multidentata through biochemical and locomotor endpoints. At 96 h of exposure, 30 and 65 µg/L glyphosate caused an increase in acetylcholinesterase (AChE) activity, and 65 µg/L glyphosate also augmented the levels of lipid peroxidation. Glyphosate at 100 µg/L did not alter the activity of acetylcholinesterase or the levels of lipid peroxidation, but it stimulated the activity of the cellular detoxification enzyme glutathione S-transferase. In addition, all concentrations affected the swimming of the fish. Under light conditions, glyphosate caused hypolocomotion at all concentrations tested, whereas under dark conditions, this was observed at 30 and 100 µg/L. Hyperlocomotion was observed at 65 µg/L glyphosate. These findings are alarming for the health of fish, such as J. multidentata that inhabit streams that pass through agricultural areas, especially for the early life stages of these fish. Research studying the effects of pollutants on native species is relevant to improve regulation that protects aquatic ecosystems.PMID:37603055 | DOI:10.1007/s00244-023-01015-z
Source: Archives of Environmental Contamination and Toxicology - Category: Environmental Health Authors: Source Type: research