Engineered hematopoietic and immune cells derived from human pluripotent stem cells

Hematopoietic stem cells (HSCs) are crucial for the formation of functional myeloid and lymphoid cells [1 –3], and their perturbations have been linked to several hematological diseases [4–6]. Hematopoietic cell transplantation (HCT) is a widely used therapeutic strategy for treating these diseases [7,8]; however, the lack of a scalable and off-the-shelf cell source of HSCs limits their application [9–11]. In this regard, human pluripotent stem cells (hPSCs) represent a promising alternative source of transplantable HSCs and provide a unique platform for studying human hematopoiesis [11–14].

Source: Experimental Hematology - August 21, 2023 Category: Hematology Authors: Yun Chang, Sydney N Hummel, Juhyung Jung, Gyuhyung Jin, Qing Deng, Xiaoping Bao Tags: Review Source Type: research