Antimicrobial Pharmacokinetics and Dosing in Critically Ill Adults Receiving Prolonged Intermittent Renal Replacement Therapy: A Systematic Review

ConclusionsThis systematic review updates and addresses issues of quality in previous systematic reviews on this topic. Despite an overall low quality of evidence, strong recommendations were able to be made for almost half of the identified antimicrobials. Knowledge gaps persist for many antimicrobials and higher quality studies (i.e., population PK studies with assessment of PD target attainment) are needed to address these gaps.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 20, 2023 Category: Drugs & Pharmacology Authors: Arvind Grewal, Pierre Thabet, Samuel Dubinsky, Debanjali Purkayastha, Kristy Wong, Ryan Marko, Swapnil Hiremath, Brian Hutton, Salmaan Kanji Tags: REVIEW Source Type: research