Cyclosporine in acute ischemic stroke

Conclusions: Cyclosporine was generally not effective in reducing infarct size. However, a smaller infarct size was observed in patients with proximal cerebral artery occlusion and efficient recanalization. Classification of evidence: This study provides Class I evidence that in patients with an acute anterior-circulation stroke, thrombolysis plus IV cyclosporine does not significantly decrease 30-day MRI infarct volume compared with thrombolysis alone.

http://www.neurology.org/cgi/content/short/84/22/2216?rss=1

Source: Neurology - June 1, 2015 Category: Neurology Authors: Nighoghossian, N., Berthezene, Y., Mechtouff, L., Derex, L., Cho, T. H., Ritzenthaler, T., Rheims, S., Chauveau, F., Bejot, Y., Jacquin, A., Giroud, M., Ricolfi, F., Philippeau, F., Lamy, C., Turc, G., Bodiguel, E., Domigo, V., Guiraud, V., Mas, J.-L., Op Tags: Clinical trials Randomized controlled (CONSORT agreement), Class I, Infarction ARTICLE Source Type: research