Characterization of < em > Mycobacterium abscessus < /em > colony-biofilms based on bi-dimensional images

Antimicrob Agents Chemother. 2023 Aug 11:e0040223. doi: 10.1128/aac.00402-23. Online ahead of print.ABSTRACTMycobacterium abscessus biofilm aggregates have been shown in the lungs of cystic fibrosis patients and are often tolerant to drugs. Herein, we analyzed bi-dimensional images of either fluorescent or Congo red-stained M. abscessus colony-biofilms grown on a membrane to monitor growth and shape of M. abscessus smooth and rough variants. These colony-biofilms responded differently to rifabutin and bedaquiline, thus highlighting the importance of the morphotype to properly address antibiotic treatment in patients with biofilm-related infections.PMID:37565746 | DOI:10.1128/aac.00402-23
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research