Disulfidptosis: disulfide stress-induced cell death

Trends Cell Biol. 2023 Aug 12:S0962-8924(23)00141-1. doi: 10.1016/j.tcb.2023.07.009. Online ahead of print.ABSTRACTThe cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress-induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.PMID:37574347 | DOI:10.1016/j.tcb.2023.07.009

Source: Trends in Cell Biology - August 13, 2023 Category: Cytology Authors: Xiaoguang Liu Li Zhuang Boyi Gan Source Type: research