Biologic therapy in psoriasis and eye

Psoriasis is a systemic inflammatory disorder, manifested mainly by skin lesions, but the inflammation may affect also the joints and eye. Many comorbidities were described in association with psoriasis, including metabolic syndrome and coronary plaques. The pathomechanism of psoriasis is multifaceted. Both genetic and immunologic aspects play a role in stimulating inflammation. Genetic susceptibility is conditioned by presence of the HLA-C*06:02 risk allele and the inflammatory reaction secondary to cytokines, like tumor necrosis factor alfa (TNF-alfa), interleukin-17 (IL-17), interleukin-20 (IL-20), interleukin-23 (IL-23) and interferon alfa.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research