Estimates of Drug Metabolism Using Drug Excretion Concentrations

Ann Clin Lab Sci. 2023 May;53(3):460-468.ABSTRACTWe propose that quantitative urine drug concentrations from LC-MS/MS measurements can be used to estimate zero and first order pharmacokinetics of the drugs oxycodone, hydrocodone, buprenorphine, methadone, and fentanyl. We observed the ratio of metabolite to parent drug could be used for this estimate. As the amount of observed parent drug increased, the metabolic ratio decreased, indicating a shift from first order to zero order metabolism. After making assumptions of bioavailability, percent of drug excreted into urine, we developed estimates of the saturating dosages for these drugs.PMID:37437938
Source: Annals of Clinical and Laboratory Science - Category: Laboratory Medicine Authors: Source Type: research