Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4

Conclusions
Our findings uncovered the significant role of aaRSs as a novel alarmin in RA pathogenesis, indicating that their blocking agents are potent antirheumatic drugs.

Source: Annals of the Rheumatic Diseases - August 11, 2023 Category: Rheumatology Authors: Kimura, A., Takagi, T., Thamamongood, T., Sakamoto, S., Ito, T., Seki, I., Okamoto, M., Aono, H., Serada, S., Naka, T., Imataka, H., Miyake, K., Ueda, T., Miyanokoshi, M., Wakasugi, K., Iwamoto, N., Ohmagari, N., Iguchi, T., Nitta, T., Takayanagi, H., Yam Tags: ARD, Rheumatoid arthritis Source Type: research