Changes in Urinary Uric Acid Concentration after Dotinurad Administration to Patients with Hyperuricemia: A Post Hoc Analysis of Two Clinical Trials in Japan

This study highlights the significance of adequately managing urinary uric acid concentrations by increasing urine volume and alkalinizing urine to prevent uric acid crystallization during dotinurad administration.

Source: Clinical Pharmacology in Drug Development - August 10, 2023 Category: Drugs & Pharmacology Authors: Toshinari Takahashi, Minoru Sasaki, Toru Shimizu, Satoshi Yamaguchi Tags: Original Article Source Type: research