Identification of a novel RSRC1-ALK (R6: A20) fusion using next-generation sequencing technique

Anaplastic lymphoma kinase (ALK) gene, initially discovered in 1994, is reported as a fusion gene in anaplastic large cell lymphoma [1]. It is located on the short arm of chromosome 2 (2p23), belonging to the insulin receptor superfamily [2]. The prevalence of ALK gene fusion and/or rearrangement is approximately 5%-6% among the non-small-cell lung cancer (NSCLC) patients [3,4], especially the never-smoking adenocarcinoma patients with no other oncogenic driver mutations [5]. To date, ALK fusion screening contributes to the identification of patients that may benefit from the ALK-targeted therapies.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research