Can a Propensity Score Matching Method be Applied to Assessing Efficacy from Single ‐Arm Proof‐of‐Concept Trials in Oncology?

In this study, we demonstrated the feasibility of using the propensity score matching (PSM) method to improve decision-making by matching relevant baseline features between current and historical cohorts. According to our findings, utilizing the PSM method may provide a less biased means of comparing outcomes between current and historical cohorts relative to a na ïve approach, which relies solely on differences in average outcomes between the cohorts.
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ARTICLE Source Type: research