E-097 Acute ischemic stroke thrombus proteome is associated with time since last known well

ConclusionsThis study points, for the first time, to differences in the proteomic landscapes between thrombi from AIS patients that are related to time since symptom onset. Taken together, the present data support a view of the stroke thrombus as a living, dynamic microenvironment with increasing intracellular protein and RNA processing with increased tLKW. More work is required to further characterize early and late stroke thrombi, as a changing clot landscape may directly underlie responsiveness to treatment.Disclosures S. Akkipeddi: None. R. Rahmani: None. N. Ellens: None. G. Kohli: None. D. Schartz: None. S. Chittaranjan: None. T. Bhalla: None. T. Mattingly: None. C. Morrell: None. M. Bender: None.

Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Akkipeddi, S., Rahmani, R., Ellens, N., Kohli, G., Schartz, D., Chittaranjan, S., Bhalla, T., Mattingly, T., Morrell, C., Bender, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research