Organoid cultures as model systems to study disorders of the human endometrium and placenta

Studying the underlying pathogenesis of disorders of the endometrium and of human pregnancy is challenging due to the lack of good in  vivo and animal models. The development of organoid cultures has provided new opportunities to perform experiments in humans that recapitulate the in vivo situation. Endometrial organoids can be derived from tissues or menstrual fluid and respond robustly to ovarian hormones. Placental trophobla st organoids can only be generated from placentas under 9 weeks gestation.

Source: Obstetrics, Gynaecology and Reproductive Medicine - July 28, 2023 Category: OBGYN Authors: Ashley Moffett Tags: Spotlight Source Type: research