Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C ‐reactive protein in white British population

ConclusionPA mutation burdens in theCRP andG6PC genes are strongly associated with decreased serum CRP concentrations. As serum CRP and obesity are important predictors of cardiovascular risks in clinics, our observations suggest taking rare genetic factors into consideration might improve the delivery of precision medicine.

Source: Molecular Genetics & Genomic Medicine - July 26, 2023 Category: Genetics & Stem Cells Authors: Xia Li, Alexander Ploner, Yunzhang Wang, Jonathan K. L. Mak, Yi Lu, Patrik K. E. Magnusson, Juulia Jylh ävä, Sara Hägg Tags: ORIGINAL ARTICLE Source Type: research