Mitochondria during T cell aging

Semin Immunol. 2023 Jul 18;69:101808. doi: 10.1016/j.smim.2023.101808. Online ahead of print.ABSTRACTMitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is characterized by alterations of the mitochondrial DNA, reduced respiratory capacity, decreased mitochondrial membrane potential and increased reactive oxygen species production. These primary alterations disrupt other interconnected and important mitochondrial-related processes such as metabolism, mitochondrial dynamics and biogenesis, mitophagy, calcium homeostasis or apoptosis. In this review, we gather the current knowledge about the different mitochondrial processes which are altered during aging, with special focus on their contribution to age-associated T cell dysfunction and inflammaging.PMID:37473558 | DOI:10.1016/j.smim.2023.101808
Source: Seminars in Immunology - Category: Allergy & Immunology Authors: Source Type: research