ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct II: Bafilomycin-sensitive H+ secretion.

CONCLUSIONS: 1) in CCDs from aldosterone-treated mice, benzamil application stimulates HCl secretion mediated by the apical H(+)-ATPase and a yet to be identified conductive Cl(-) transport pathway. 2) Benzamil-induced HCl secretion is reversed with the application of stilbene inhibitors or H+-ATPase inhibitors to the perfusate. 3) Benzamil reduces VT not only by inhibiting conductive Na+ absorption, but also by stimulating H(+) secretion. PMID: 26017972 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research