Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model

Experimental & Molecular Medicine, Published online: 18 July 2023; doi:10.1038/s12276-023-01044-7A Drosophila fly model of an inherited form of the eye disease retinitis pigmentosa has revealed a signaling and control pathway involving the intracellular endoplasmic reticulum structure that leads to cell death. Retinitis pigmentosa is an age-related disease of the retina of the eye, leading to progressive vision loss. It is known to involve dysfunction of the endoplasmic reticulum, which, among other functions crucial for cell health, is essential for the synthesis of many proteins. Researchers in South Korea led by Min-Ji Kang at the University of Ulsan College of Medicine identified specific genes and proteins involved in their Drosophila model of RP, which may also be significant in human disease. These insights may contribute to preventing the progression of retinitis pigmentosa in human patients.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research