Therapeutic drug monitoring of voriconazole and CYP2C19 phenotype for dose optimization in paediatric patients

ConclusionsThe VRC plasma trough concentration is significantly influenced by the CYP2C19 phenotype. The recommended maintenance dose for pediatric patients may not be appropriate for Chinese patients. To increase the probability of achieving the therapeutic range for VRC plasma trough concentration, the administration of VRC should consider the age of paediatric patients and the presence of CYP2C19 polymorphisms.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research