A new era for glioma therapy — targeting mutant IDH

Nature Reviews Clinical Oncology, Published online: 17 July 2023; doi:10.1038/s41571-023-00804-8Hotspot point mutations in IDH1 occur in the vast majority of adult grade 2–3 gliomas. The understanding of their role in tumour biology continues to evolve. Therapeutic targeting of mutant IDH1 with vorasidenib demonstrated highly encouraging efficacy and minimal toxicity in a recent, randomized phase III trial involving patients with low-grade gliomas.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research