Management of Local –Regional Recurrence of Breast Cancer

AbstractPurpose of ReviewLocoregional recurrence (LRR) of breast cancer represents a heterogenous spectrum of disease. Treatment strategies are tailored to each patient and are impacted by multiple factors. The intent of this review is to discuss recent studies and modern management of isolated LRR.Recent FindingsFor selected patients with small ipsilateral breast tumor recurrences, partial-breast irradiation following repeat breast-conserving surgery may be appropriate with acceptable rates of toxicities and promising local control. Over the past decade, numerous systemic therapies for the neoadjuvant or adjuvant treatment of early-stage primary breast cancer have been shown to improve oncologic outcomes. Patients with recurrences were not included in these trials yet may benefit from these newer agents.SummaryThe management of patients with LRR is complex and is influenced by initial treatments, location of recurrence, and hormone and HER-2 receptor status. Patients with isolated LRR have potentially curable disease, and often warrant aggressive multimodality treatment. The addition of systemic therapy remains an area in great need of clinical research.
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research