A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis

In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001

Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research