Metformin reduces bone resorption in apical periodontitis through regulation of osteoblast and osteoclast differentiation

We have previously demonstrated that auxiliary metformin therapy promotes healing of apical periodontitis. Here we aimed to investigate the effects of metformin on osteoblast differentiation and osteoclast formation in cultured cells and rat apical periodontitis.

Source: Journal of Endodontics - July 13, 2023 Category: Dentistry Authors: Chi-Yuan Hong, Sze-Kwan Lin, Han-Wei Wang, Chia-Tung Shun, Cheng-Ning Yang, Eddie Hsiang-Hua Lai, Shih-Jung Cheng, Mu-Hsiung Chen, Hsiang Yang, Hung-Ying Lin, Fang-Yu Wu, Sang-Heng Kok Tags: Basic Research-Biology Source Type: research