Recombinant < em > Fowl aviadenovirus E < /em > (FAdV-E) penton base vaccination fails to confer protection against inclusion body hepatitis (IBH) in chickens

Avian Pathol. 2023 Jul 7:1-6. doi: 10.1080/03079457.2023.2226085. Online ahead of print.ABSTRACTInclusion body hepatitis (IBH) is a metabolic disease affecting chickens, associated with different serotypes of fowl adenovirus (FAdV). Experimentally tested vaccines against IBH include several capsid-based subunit vaccines, but not the penton base protein. In the present study, specific pathogen-free chickens were vaccinated with recombinant penton base expressed from each of two different FAdV serotypes (FAdV-7 and FAdV-8b), followed by challenge with a virulent IBH-causing strain. No protection was observed with either vaccine, possibly due to the low immunogenicity of each protein and their inability to induce neutralizing antibodies in the host.PMID:37416969 | DOI:10.1080/03079457.2023.2226085
Source: Avian Pathology - Category: Pathology Authors: Source Type: research